It is not known if ACIPHEX is certainly effective and safe if used longer than 12 months .For four weeks to take care of daytime and nighttime heartburn and other symptoms that happen with Gastroesophageal Reflux Disease .GERD happens when acid in your stomach backs up into the tube that connects your mouth to your stomach. This may cause a burning feeling in your throat or chest, sour taste, or burping.for 4 weeks for the recovery and relief of duodenal ulcers.The median period from the initial medical diagnosis of CLL to transformation was 98 weeks . Among the 11 sufferers in whom progressive disease developed, 10 individuals had a 17p13.1 or a 11q22.3 deletion, and 1 patient did not have high-risk cytogenetic abnormalities . Sufferers had a prolonged time to progression despite high-risk genomic features. Among the 28 patients with a 17p13. Individuals who discontinued ibrutinib for factors other than progression remained in the analysis and were adopted quarterly until disease progression, the initiation of new anticancer therapy, or loss of life. After disease initiation or progression of subsequent anticancer therapy, follow-up was limited to survival status. Treatment at the right period of new treatment initiation was still left to the discretion of the treating physician.