Next, a similarity metric was computed to quantify how closely the activity in the parts of interest on each communication scan matched each localizer scan. Results Responses to the Imagery Tasks Among the 54 individuals, we identified 5 who could willfully modulate their brain activity . In every five of the patients, the functional MRI scans connected with motor imagery, in comparison with spatial imagery, demonstrated significant activation in the supplementary engine region.Plasma corticotropin amounts were measured in samples of right and remaining adrenal and peripheral venous blood from Sufferers 12 and 13 . The same procedure was adopted for the 5 control individuals with aldosterone-producing adenomas. We used a solid-phase, two-site sequential chemiluminescence immunometric assay with a lower limit of detection of 2 ng per liter .12 Information on the techniques used for these research are provided in the Materials and Methods section and Tables S3 through S6 in the Supplementary Appendix. Study Oversight The protocols for the collection of adrenal samples and the experimental procedures were approved by the regional ethics committees.