Michael P. Whyte, M.D., Cheryl R. Greenberg, M.D., Nada J. Salman, M.D., Michael B. Bober, M.D., Ph.D., William H. McAlister, M.D., Deborah Wenkert, M.D., Bradley J. Van Sickle, M.D., Ph.D., Jill H. Simmons, M.D., Terence S. Edgar, M.D., Martin L. Bauer, M.D., Mohamed A. Hamdan, M.D., Nick Bishop, M.D., Richard E. Lutz, M.D., Mairead McGinn, M.D., Stanley Craig, M.D., Jean N. Moore, M.D., John W. Taylor, D.O., Robert H. Cleveland, M.D., William R. Cranley, M.D., Ruth Lim, M.D., Tom D. Thacher, M.D., E Jill. Mayhew, P.T., Matthew Downs, M.P.H.D., Alison M. Skrinar, M.P.H., Philippe Crine, Ph.D., and Hal Landy, M.D.: Enzyme-Replacement Therapy in Life-Threatening Hypophosphatasia.The two primary antibiotics you should definitely avoid drinking alcohol with are metronidazole and tinidazole . These antibiotics are accustomed to treat various infections including: dental care and vaginal infections infected leg ulcers and pressure sores some stomach or gut infections Additional antibiotics that may cause adverse effects when used with alcoholic beverages are co-trimoxazole and linezolid . Co-trimoxazole is used to prevent and treat whooping cough and various other bacterial infections. Linezolid is a rarely used antibiotic but may be necessary to treat serious attacks when other antibiotics are not suitable. With what mechanism does alcoholic beverages cause these symptoms? Metronidazole and tinidazole may hinder the breakdown of alcohol in the body, and can trigger unpleasant symptoms like nausea, vomiting, skin flushes, head aches, or a fast or irregular heartbeat.