Thus, up to half of the folate related neural tube defects could be explained by this solitary genetic variant. Both lower folate and higher homocysteine levels connected with CT and TT genotypes can be corrected by folic acid, explain the authors. Consequently, this research underscores the importance of public health intervention programmes of folic acid supplementation and food fortification targeted at all females of childbearing age group to prevent neural tube defects. Such intervention could also result in have other public health advantages, such as the prevention of heart disease, they conclude..AP214 is in development to prevent acute kidney damage connected with major cardiac medical procedures in patients at improved risk and has additional potential in adjacent indications. AP214 is usually a hormone analogue that targets both systemic irritation and cellular death due to hypoxia that may occur during medical procedures. In September 2011, Action Pharma announced positive Phase 2b top-line outcomes evaluating the efficacy, security and tolerability of AP214. Abbott plans to conduct another Phase 2b study, which is expected to begin later this year. This acquisition will enhance Abbott’s pipeline in renal care. Abbott has two investigational remedies in development for chronic kidney disease .