Added advantage of ipilimumab in advanced melanoma not confirmed for non-pretreated patients Indirect comparison of individual individual data biased and uncertain, hence results weren’t interpretable The German Institute for Quality and Efficiency in HEALTHCARE currently assessed the added advantage of ipilimumab in advanced melanoma in 2012. A significant added advantage was found for individuals who had currently received previous treatment.Study results presented at meetings are generally considered preliminary until they are released in a peer-reviewed journal. At one time, menopausal women were approved hormone therapy to help ward off heart disease routinely. That all transformed in 2002, when researchers reported the findings from the Women’s Wellness Initiative , a large U.S. Scientific trial that tested oral hormone therapy against a placebo. Unlike everyone’s expectations, the trial discovered that hormones – – by means of estrogen in addition progesterone – – raised women’s threat of blood clots, heart attack, stroke and breast cancers.