Maurizio Macaluso.

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‘The long reads of the GS FLX+ System allow for accurate assembly of genes and their splicing variants, which continues to be a challenge with short read systems’, he described. The study, published online this week in the Proceeding of National Academy of Sciences, used a combined mix of the new GS FLX+ System’s long reads, GS FLX Titanium paired end reads and short read data to sequence and assemble the 3.2 billion base set genomes of two Tasmanian devils, one with natural resistance to some DFTD strains, and the various other who had contracted the disease in the wild. ‘A defining part of this project was the capability to create on the GS FLX+ System the longer, accurate reads had a need to develop a full knowledge of the genetic makeup of the Tasmanian devil,’ explained Stephan Schuster, senior author and Professor of Biochemistry and Molecular Biology at Penn State University.