The question of whether specific time windows were associated with the health effects was investigated by subdividing the follow-up interval into four periods . Exposures were matched for every of these periods and also tested for a 10-year average based on the 5-yr follow-up period and the 5 years before the follow-up period . Results The analytic cohort included 448,850 subjects surviving in 96 metropolitan statistical areas . In 1980, the populations of these 96 areas ranged from 94,436 to 8,295,900. Data had been available on the concentration of ambient ozone from all 96 areas and on the focus of PM2.5 from 86 areas.76 million people get sick in US, 300,000 are hospitalized, and 5,000 die from foodborne illness Foodborne illnesses have a significant open public health impact in the United States. It’s estimated that every year in the United States, 76 million people obtain sick, a lot more than 300,000 are hospitalized, and 5,000 die as a result of foodborne illnesses, primarily the very young, elderly, and the immunocompromised. Unfortunately, substantial progress in preventing certain foodborne ailments such as typhoid and cholera offers resulted in complacency in both the general public and the medical occupation. This, coupled with recent changes in human demographics and eating behavior, technology and industry, international travel and commerce, microbial adaptation, economic advancement and land make use of, and the breakdown of public health actions, has resulted in fresh and reemerging foodborne ailments.