This content is definitely republished with kind authorization from our close friends at The Kaiser Family members Foundation. You can view the complete Kaiser Daily Health Plan Survey, search the archives, or sign up for email delivery of in-depth coverage of wellness policy developments, discussions and debates. The Daily Health Plan Report is released for Kaisernetwork.org, a free program of The Henry J. Kaiser Family Foundation. Copyright 2009 Advisory Board Organization and Kaiser Family Basis. All rights reserved.. Organizations probe Merck for foreign anti-bribery law violations Merck, the next biggest international drug maker, is being investigated by two U.S.Even though wild-type GNRH1 expression plasmid created robust amounts of GnRH, no significant GnRH peptide expression was detected in the c.18-19insA mutant construct, demonstrating the inability of the mutant to create the normal decapeptide. Two decades ago, the GnRH-associated peptide , which is encoded by GNRH1,27,28 was reported to be a potent inhibitor of prolactin secretion in cultures of rat pituitary cells, and active immunization with peptides corresponding to GAP sequences was proven to increase prolactin secretion in rabbits.30 It is noteworthy that both subjects described here got normal plasma prolactin amounts despite transporting homozygous frameshift mutations that resulted in the putative translation of an aberrant peptide, completely lacking the GAP peptide sequence also.