Researchers from PharmAbcine are suffering from DIG-KT, a bi-specific mAb to treat solid tumors. DIG-KT binds VEGFR2/KDR and Tie-2 simultaneously, and blocks binding of VEGFR2 ligands, including VEGF-A, VEGF-C and VEGF-D, in addition to Tie-2 ligands, including Ang1, Ang2, Ang4 and Ang3. Therefore, DIG-KT inhibits ligand-stimulated activations of both VEGFR2/KDR and Tie-2, inhibits ligand-induced angiogenesis therefore, proliferation, and migration of individual endothelial cells. Current anti-VEGF drugs such as bevacizumab, sorafenib and aflibercept are efficacious. Still, over time cancer cells develop resistance via induction of ANG/Tie-2 pathway, another route to angiogenesis.Department of Human and Health Services, functions to enhance the quality, safety, efficiency, and effectiveness of healthcare in the usa. The data in this AHRQ Information and Numbers summary are taken from the Medical Expenditure Panel Survey, a detailed way to obtain details on the ongoing health services utilized by Americans, the frequency with that they are used, the price of those ongoing solutions, and how they are paid. For more information, go toArthritis: Use and Expenditures among U.S.